Acta biomaterialiaAnimalsArthritisRheumatoidCell-Free Nucleic AcidsMice
Helix-guarded molecular clips confer robust scavenging of intra-articular cell-free DNA for the treatment of rheumatoid arthritis.
Yang Zhou, Chenglong Ge, Mengyuan Yin, Yekun Deng, Zhongmin Liu, Jingrui Shen, Renxiang Zhou, Lichen Yin
Published: 202610.1016/j.actbio.2025.12.010
Abstract
The disruption of immune homeostasis induced by cell-free DNA (cfDNA) plays a critical role in the pathogenesis of rheumatoid arthritis (RA). Intra-articular injection of cationic polymers represents a promising RA treatment modality, because they ca…
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