Acta biomaterialiaOxygenBasic Helix-Loop-Helix ProteinsLiverAnimalsHumans
A physiological oxygen gradient liver-zonation-on-a-chip reveals HIF-2α intervention in hepatic lipotoxicity.
Yushen Wang, Xinyu Li, Junlei Han, Feng Kong, Zhipeng Xu, Huili Hu, Li Wang
Published: 202610.1016/j.actbio.2025.11.044
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease characterized by lipid zonation, which is closely linked to the functional zonation of liver lobules. However, existing models cannot faithfully replicate t…
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