Analytica chimica actaHumansClass I Phosphatidylinositol 3-KinasesTemperatureMutationGene Frequency
Dual-mode temperature-switchable TSCP probes for precise analysis of PIK3CA mutations and VAF.
Xueqiang Wu, Xuyang Pu, Nating Xiong, Hui Rao, Yinmei Zhang, Tai Xu
Published: 202610.1016/j.aca.2025.345010
Abstract
BACKGROUND: Precision oncology requires robust methods for simultaneous mutation detection and variant allele frequency (VAF) quantification to guide therapeutic decisions. Current technologies face limitations in sensitivity, cost, and workflow comp…
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