Analytica chimica actaHydrophobic and Hydrophilic InteractionsOligonucleotidesSolid Phase ExtractionHumansChromatography
Development of a hydrophilic interaction-based procedure for the extraction, separation, and determination of therapeutic oligonucleotides.
Zuzana Vosáhlová, Szymon Bocian, Sylwia Studzińska
Published: 202610.1016/j.aca.2025.344808
Abstract
BACKGROUND: For analyzing oligonucleotide impurities and metabolites in serum samples, where mass spectrometry detection is essential, hydrophilic interaction liquid chromatography utilizing fully mass spectrometry compatible mobile phases is the bes…
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