Archives of biochemistry and biophysicsCopperStaphylococcus aureusCatalytic DomainCysteineProtein Binding
Glyceraldehyde-3-phosphate dehydrogenase is inhibited by binding of Cu(I) to the essential active site cysteine.
Gustavo Pelicoli Riboldi, Samantha J Firth, Arnaud Baslé, Kevin J Waldron
Published: 202610.1016/j.abb.2025.110707
Abstract
Copper is an essential micronutrient for bacteria, needed for important copper enzymes such as terminal respiratory oxidases. However, in excess, copper is toxic to bacteria. This toxicity is caused by its ability to bind tightly to proteins through…
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