Archives of biochemistry and biophysicsSulfonamidesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCarbonic Anhydrase IXHumans
A comprehensive review of the structural basis for the selectivity of sulfonamide-based inhibitors for carbonic anhydrase isoforms IX and XII over carbonic anhydrase II based on the available high quality crystallographic data.
Sarfraz Ahmad, Muhammad Usman Mirza, Mamoona Nazir, Lee Yean Kee, Noorsaadah Binti Abd Rahman, Iskandar Abdullah, John F Trant
Published: 202610.1016/j.abb.2025.110682
Abstract
Hypoxia in solid tumours induces carbonic anhydrases (CAs) upregulation, notably CA IX and CA XII, to sustain pH homeostasis. While sulfonamide-based zinc binders show high affinity for these targets, achieving the required selectivity versus the ubi…
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