Archives of biochemistry and biophysicsSaccharomyces cerevisiaeAdenosine DiphosphateSaccharomyces cerevisiae ProteinsMitochondrial Proton-Translocating ATPasesMutation
γM23K mutation enhances ADP inhibition of mitochondrial F-ATPase yet has a minor effect on yeast growth rate.
Valeria M Zubareva, Kseniia V Galkina, Anna S Lapashina, Svyatoslav S Sokolov, Olga V Markova, Dmitry A Knorre, Boris A Feniouk
Published: 202610.1016/j.abb.2025.110674
Abstract
ADP inhibition of ATP hydrolysis is a conserved regulatory mechanism found in virtually all F-type ATP synthases. It occurs when ADP binds tightly to a catalytic site in the absence of phosphate, locking the enzyme in an inactive conformation. This i…
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