Archives of biochemistry and biophysicsFerroptosisReperfusion InjurySTAT3 Transcription FactorAnimalsBasic-Leucine Zipper Transcription Factors
BACH1 drives ferroptosis in lung ischemia-reperfusion injury through epigenetic suppression of STAT3-Mediated antioxidant defense.
Ying Gu, Xiuli Liu, Xiaojun Zhang, Ning Zhang
Published: 202610.1016/j.abb.2025.110669
Abstract
BACKGROUND: Lung ischemia-reperfusion injury (LIRI) is a major complication in lung transplantation, with ferroptosis as a key mechanism. The role of BACH1, a regulator of oxidative stress and iron metabolism, in LIRI-associated ferroptosis is unclea…
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