Archives of biochemistry and biophysicsHumansNF-E2-Related Factor 2Reactive Oxygen SpeciesMitochondriaHeLa Cells
Thermotolerance induced by non-lethal heat shock at 40 °C is activated by mitochondrial ROS and is Nrf2-dependent.
Georges Hraoui, Mélanie Grondin, Khadija Rezki, Diana A Averill-Bates
Published: 202610.1016/j.abb.2025.110649
Abstract
Hyperthermia is generally administered as an adjuvant to chemotherapy/radiotherapy and sensitizes tumors to these anticancer treatments. Repeated heat treatments (≥42 °C) cause development of transient thermotolerance, an adaptive survival response.…
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