Archives of biochemistry and biophysicsMicroRNAsLysophospholipidsExtracellular VesiclesReceptorsLysophosphatidic Acid
TNF promotes osteoclastogenesis by secreting miR-31-5p into small extracellular vesicles via the autotaxin-LPA-LPAR1 axis in arthritic fibroblast-like synoviocytes.
Thanh Nam Phan, Minju Gal, Okhwa Kim, Hoang Long Le, Cheol Hwangbo, Jeong-Hyung Lee
Published: 202510.1016/j.abb.2025.110631
Abstract
Fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis of arthritis. However, the impact of small extracellular vesicles (sEVs) secreted by FLSs on osteoclastogenesis remains incompletely understood. In this study, we aimed to in…
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