Methods in enzymologyCytochrome P-450 Enzyme SystemBiocatalysisProtein EngineeringOxidation-ReductionMacrocyclic Compounds
Biaryl coupling reactions catalyzed by cytochrome P450s.
Carmela Molinaro, Yukie Kawasaki, Tsuyoshi Yamamoto
Published: 202510.1016/bs.mie.2025.08.013
Abstract
Biaryl coupling reactions are pivotal in the synthesis of complex therapeutic compounds, such as michelline B, vancomycin and arylomycin A2 derivatives. Synthesizing macrocycles, particularly the 2,2'-disubstituted biaryl-bridged peptide in arylomyci…
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