Methods in enzymologyTransketolaseHumansEnzyme InhibitorsMolecular Docking SimulationProtein Binding
Evaluation of binding, affinity and metabolic regulatory activity of a transketolase inhibitor.
Dan Jia, Chunliang Liu, Wenyu Liu, Jing Fu, Xiaofei Chen, Hong-Yang Wang
Published: 202510.1016/bs.mie.2025.07.012
Abstract
Transketolase (TKT), a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway, plays a critical role in metabolic processes including nucleotide synthesis and tumorigenesis. Its inhibitors could modulate the enzyme acti…
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