Advances in protein chemistry and structural biologyHumansTumor Suppressor Protein p53NeoplasmsAnimalsProtein Aggregates
p53 Aggregation in cancer: Molecular mechanisms, functional disruptions, and targeted therapies.
Asma Shah, Sara K AlMarzooqi, Sameer Mirza, Ammira S Al-Shabeeb Akil, Mayank Singh, Muzafar A Macha, Ajaz A Bhat
Published: 202510.1016/bs.apcsb.2025.08.015
Abstract
The concept of tumors as prion-like diseases similar to neurodegenerative disorders has gained attraction in recent years. p53, the most well-known tumor suppressor, has been extensively studied for its expression, mutations, and functions in various…
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