The Lancet. HaematologyHumansMultiple MyelomaCyclophosphamideDexamethasoneMale
Iberdomide plus low-dose cyclophosphamide and dexamethasone in patients with relapsed and refractory multiple myeloma (the ICON study): a multicentre, single-arm, phase 2 trial.
Charlotte L B M Korst, Wouter Plattel, Elizabeth A de Kort, Febe Smits, Alexandra J Croockewit, Mark-David Levin, Matthijs Westerman, Okke de Weerdt, Inger S Nijhof, Jurgen Wegman, Nina Smit, Christie P M Verkleij, Tuna Mutis, Kazem Nasserinejad, Ramses Kerstiens
Published: 202610.1016/S2352-3026(25)00298-4
Abstract
BACKGROUND: Iberdomide is an oral cereblon E3 ligase modulator with higher affinity to cereblon than immunomodulatory drugs, leading to improved direct anti-myeloma activity and enhanced immunostimulatory effects. We aimed to evaluate the safety and…
Preview only. Read the full abstract at the source