The Lancet. HaematologyHumansLeukemiaLymphocyticChronicB-Cell
Fixed-duration ibrutinib-venetoclax with MRD-guided ibrutinib-obinutuzumab intensification in first-line chronic lymphocytic leukaemia (HOVON 158/NEXT STEP): primary analysis of a multicentre, open-label, phase 2 trial.
Arnon P Kater, Sabina Kersting, Julie M Dubois, Bronno van der Holt, Caspar da Cunha-Bang, Doreen Te Raa, Cecile Idink, Fransien de Boer, Jolanda Droogendijk, Koen de Heer, Leonie van der Burg, Marten R Nijziel, Lidwien Tick, Henriette Levenga, Matthijs Silbermann
Published: 202510.1016/S2352-3026(25)00288-1
Abstract
BACKGROUND: Triplet regimens combining a Bruton's tyrosine kinase inhibitor, B-cell lymphoma 2 inhibitor, and anti-CD20 antibody are among the most effective first-line treatments for chronic lymphocytic leukaemia, but come with substantial toxicity.…
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