Lancet (London, England)AdultAgedFemaleHumansMale
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial.
Deborah B Horn, Donna H Ryan, Sanja Giljanovic Kis, Breno Alves, Yiming Mu, Sin Gon Kim, Jens Aberle, Stephen C Bain, Sheryl Allen, Elizabeth Sarker, Qiwei Wu, Adam Stefanski, Irina Jouravskaya, ATTAIN-2 Trial Investigators
Published: 202610.1016/S0140-6736(25)02165-8
Abstract
BACKGROUND: Obesity is a chronic disease that significantly contributes to type 2 diabetes and its complications. We aimed to evaluate orforglipron, an oral small-molecule (non-peptide) GLP-1 receptor agonist, for obesity treatment in adults with typ…
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