Handbook of clinical neurologyHumansReceptorsFcHistocompatibility Antigens Class IAnimals
FcRn inhibitors: A new era in neurotherapeutics.
James F Howard, Jeffrey T Guptill
Published: 202610.1016/B978-0-323-90887-0.00002-X
Abstract
The neonatal Fc receptor (FcRn) is a heterodimeric protein that binds albumin and immunoglobulin G (IgG) to mediate pH-dependent recycling, prevent degradation, and maintain their serum concentrations. The ability to bind IgG means FcRn plays both be…
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