Therapeutic innovation & regulatory science
Improving the Analysis of KCCQ Endpoints in Heart Failure Clinical Trials.
Robin Myte, John Eriksson, Martin Rensfeldt, Yunyun Jiang, Ayman Al-Shurbaji, Per Nyström
Published: 202510.1007/s43441-025-00888-7
Abstract
BACKGROUND: The Kansas City Cardiomyopathy Questionnaire (KCCQ) is frequently used in heart failure (HF) clinical trials to evaluate treatment effects on function and symptoms. However, due to the 0-100 boundedness in KCCQ scores, conventional mean c…
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