Therapeutic innovation & regulatory scienceHumansResearch DesignClinical Trials as TopicMental DisordersPlacebo Effect
Estimating Treatment Effect for Target Population in Psychiatric Clinical Trials Using Placebo Lead-in Design.
Zhao Yang
Published: 202610.1007/s43441-025-00881-0
Abstract
The placebo lead-in design is commonly utilized in psychiatric clinical trials to mitigate high placebo response rates; conventional methods for estimating treatment effects typically rely solely on data from the second period, disregarding the enric…
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