Reproductive sciences (Thousand Oaks, Calif.)AnimalsFemaleFetal HypoxiaPregnancyBiomarkers
Identification of Gestation-Specific Patterns of Physiological, Protein and Cell-Free RNA Injury Markers in a Sheep Model of Regulable Preterm Fetal Hypoxia.
Haruo Usuda, Hideyuki Ikeda, Shimpei Watanabe, Erin L Johnson, Sean W D Carter, Yusaku Kumagai, Yuya Saito, Michelle Seah, Binny P Sesurajan, Tsukasa Takahashi, Noriyoshi Mochi, Kantarou Sahara, Hannah Watson, Shinichi Kawamura, Masatoshi Saito
Published: 202510.1007/s43032-025-02005-3
Abstract
Fetal hypoxia remains a major unresolved clinical challenge. Using artificial placenta (AP) technology, we established a standardized model of progressive hypoxia that induces brain injury in fetal sheep. To support the development of new antenatal m…
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