Reproductive sciences (Thousand Oaks, Calif.)MaleAnimalsBlood-Testis BarrierProprotein Convertase 9Diet
A High-Fat Diet Damages the Blood-Testis Barrier Through the PCSK9-LOX1 Positive Feedback Loop in Sertoli Cells.
Gao Zhang, Zun Wang, Man He, Lingnan Kong, Suliya Yushanjiang, Lei Jin, Rongqian Zhao, Ziyang Ma, Yiran Pan, Ying Hu, Li Nie, Dongzhi Yuan
Published: 202510.1007/s43032-025-01974-9
Abstract
We primarily investigated the correlation between long-term high-fat diet and male infertility, aiming to reveal the potential mechanisms underlying PCSK9-induced spermatogenic dysfunction in this context. Clinical data revealed that infertile male p…
Preview only. Read the full abstract at the source