Clinical pharmacokinetics
Use of a Cystatin C-Based GFR Equation in a Population Pharmacokinetic Model of Methotrexate Clearance in Adult Patients with Lymphoma.
Zachary L Taylor, Erin F Barreto, Kristin C Cole, Andrew D Rule, Kianoush B Kashani, Nelson Leung, Carrie A Thompson, Thomas E Witzig, Laura B Ramsey, Jason N Barreto
Published: 202610.1007/s40262-026-01618-4
Abstract
BACKGROUND: High-dose methotrexate (HDMTX) is a key treatment for lymphoma with central nervous system involvement. Whether incorporating cystatin C into glomerular filtration rate estimation improves methotrexate (MTX) clearance prediction remains u…
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