Clinical pharmacokinetics
Population Pharmacokinetics of Total and Protein-Unbound Prednisolone in Children with Immune-Mediated and Systemic Inflammatory Diseases.
Julia E Möhlmann, Caroline A Lindemans, Marc H A Jansen, Matthijs van Luin, Arjen M Punt, Solaiman Ezzafzafi, Stefan Nierkens, Alwin D R Huitema, Aurelia H M de Vries Schultink
Published: 202510.1007/s40262-025-01601-5
Abstract
BACKGROUND AND OBJECTIVE: High-dose systemic prednisolone is the mainstay treatment of children with various (auto)immune diseases. The standard empirical dosing regimen with dosages up to 2 mg/kg/day is generally adequate for immune suppression, tho…
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