Genes & genomics
Itaconate modulates myeloid inflammation in myocardial infarction via metabolic and structural reprogramming.
Tao Zhang, Ruijinlin Hao, Chuanfu Li, Kun Yang, Lei Zhou
Published: 202510.1007/s13258-025-01698-9
Abstract
BACKGROUND: Acute myocardial infarction (AMI) is a leading cause of mortality worldwide, with sterile inflammation and immune dysregulation driving cardiac injury. Itaconate, a mitochondria-derived immunometabolite synthesized by ACOD1, has emerged a…
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