International journal of hematology
Low reticulocyte count at infusion is a risk factor for high-grade cytokine release syndrome in chimeric antigen receptor T cell therapy.
Yusuke Tashiro, Tomoyasu Jo, Toshio Kitawaki, Noriyoshi Yoshinaga, Takashi Sakamoto, Kotaro Shirakawa, Junya Kanda, Momoko Nishikori, Kouhei Yamashita, Miki Nagao, Akifumi Takaori-Kondo, Yasuyuki Arai
Published: 202510.1007/s12185-025-04109-7
Abstract
Although chimeric antigen receptor (CAR)-T cell therapies are highly effective for B-cell lymphoma, they frequently cause cytokine release syndrome (CRS). High-grade CRS is serious and may require intensive care, yet reliable early predictive markers…
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