International journal of hematology
BRD9 depletion-mediated ALOX5 upregulation via chromatin dysregulation induces ferroptosis in SF3B1-mutant hematopoiesis.
Wataru Saika, Hiromi Yamazaki, Shota Tanaka, Min Lin, Seigi Oshima, Ziyu Gao, Masaki Nomura, Weijia Zang, Yui Koike, Muran Xiao, Hiromi Ito, Naomi Matsumoto, Takaya Yamasaki, Koutarou Nishimura, Makoto Murata
Published: 202510.1007/s12185-025-04105-x
Abstract
SF3B1 mutations are among the most common splicing factor mutations in myeloid malignancies, yet the mechanisms linking aberrant splicing to metabolic phenotypes remain incompletely understood. We previously demonstrated that SF3B1 mutations cause no…
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