Hepatology international
Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma.
Fan Zhang, Zhipeng Yao, Hengjun Gao, Ruoyu Shi, Yan Xu, Chengfei Zhang, Panpan Zhao, Tao Li, Zhangjun Cheng, Yong Zha, Hongping Xia
Published: 202510.1007/s12072-025-10916-1
Abstract
BACKGROUND: RNA splicing dysregulation plays an important role in hepatocellular carcinoma (HCC). However, the critical functions of zinc finger CCHC type and RNA binding motif 1 (ZCRB1), one of the key components of the minor spliceosome, in HCC rem…
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