Exophytic left ventricular angiomyxoma.

Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor in males, predominantly arising in the pelvis or perineum. We report a unique case of a seventy-year-old male presenting with a progressive exophytic cardiac mass originating from the left ventricle (LV). Imaging revealed a well-circumscribed mediastinal tumor compressing the lung and involving cardiac structures. Surgical excision was performed with cardiopulmonary bypass support, including left lower lobectomy due to extensive lung adherence. Histopathological evaluation confirmed the diagnosis of angiomyxoma. The patient recovered uneventfully and was discharged on the tenth postoperative day. This case highlights the diagnostic challenges and multidisciplinary management of AAM involving the heart, emphasizing the importance of meticulous surgical planning and comprehensive follow-up to mitigate the risk of recurrence. Supplementary Information: The online version contains supplementary material available at 10.1007/s12055-025-02028-0.