Molecular neurobiologyAnimalsMetforminMicroRNAsBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding Protein
Metformin improves the impairment of cognitive function caused by total abdominal irradiation via the miR-34a-5p/BDNF/CREB axis.
Wang Jianyu, Juan Guo, Li Guo, Qiaohui Gao, Shengyuan Jiao, Xia Miao, Fei Da, Junye Liu
Published: 202610.1007/s12035-026-05696-0
Abstract
The gastrointestinal system is of particular importance in radiation biodosimetry because of its constant cell renewal and sensitivity to radiation-induced injury. It has been reported that total abdominal irradiation causes distant cognitive defects…
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