Molecular neurobiologyAnimalsOxidative StressSTAT3 Transcription FactorMaleLeukemia Inhibitory Factor
Time-Resolved Oxidative Stress and Apoptosis in Murine Retina under Acute Hypobaric Hypoxia with Parallel Activation of the LIF-JAK-STAT3 Axis.
Hao Wang, Qiang Ye, Songjian Huang, Keke Ge, Cong Han, Huan Xi, Junyi Qiao, Jingrong Feng, Peirun Wu, Yuhan Bao, Yi Yang, Wenfang Zhang
Published: 202610.1007/s12035-025-05639-1
Abstract
High-altitude retinopathy (HAR) arises under acute hypobaric hypoxia (AHH), yet the temporal coupling of oxidative stress, apoptosis and cytokine signaling in the retina remains unclear. We exposed healthy male C57BL/6 mice to a hypobaric chamber (≈5…
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