Molecular neurobiologyAnimalsSleep DeprivationTOR Serine-Threonine KinasesAutophagyAnxiety
Sleep Deprivation Induces Anxiety-like Behaviors in Mice by Impairing ApoE/AMPK/mTOR-Mediated Autophagy.
Xianbing Bai, Hongmei Du, Xiangxuan Liu, Wanyu Yi, Yunlu Hu, Jinru Wang, Fanzhi Yan, Zimeng Cheng, Genying Zhu, Zhiping Cao, Ming Chen, Binliang Tang
Published: 202510.1007/s12035-025-05610-0
Abstract
Sleep Deprivation (SD) severely disrupts emotional regulation, predisposing individuals to mood disturbances and anxiety. However, the precise mechanisms underlying anxiety triggered by sleep loss remain elusive. In this study, a mouse model of chron…
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