Molecular neurobiologyAnimalsInterferon Regulatory FactorsDNA-Binding ProteinsMacrophagesMice
Myeloid Irf5 Deficiency Enhances the Therapeutic Efficacy of IMD-0354 in a TDP-25-Induced Neurodegeneration Model.
Yuanyuan Li, Yuan Zhou, Lishuang Yu, Yue Bi, Le Yi, Chunyan Li, Yakun Liu
Published: 202510.1007/s12035-025-05606-w
Abstract
Neuroinflammation is recognized as a key contributor to the pathogenesis and progression of amyotrophic lateral sclerosis (ALS), with dysregulated innate immune activation implicated in exacerbating neuronal injury. However, the molecular mechanisms…
Preview only. Read the full abstract at the source