Molecular neurobiologyAnimalsReperfusion InjuryMetforminNLR FamilyPyrin Domain-Containing 3 Protein
Metformin Improves Cognitive Function in a Rat Model of Global Cerebral Ischemia/Reperfusion Injury Via Inhibiting NF-kb Signaling Pathway and Caspase-1/NLRP3 Inflammasome.
Zohreh Lamoochi, Seyed Esmaeil Khoshnam, Maryam Khombi Shooshtari, Mohammad Badavi, Yaghoub Farbood, Alireza Sarkaki
Published: 202610.1007/s12035-025-05492-2
Abstract
Ischemic stroke is among the important causes of death globally, with many survivors experiencing considerable cognitive deficits. This study explored metformin (Met)'s therapeutic effects in a global cerebral ischemia-reperfusion (I/R) injury model…
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