Molecular neurobiologytau ProteinsNeuronsAnimalsCerebral CortexPhosphorylation
Cross-Talk Between Tau O-GlcNAcylation and the Formation of the Early Driver of Neurodegeneration (Cis P-Thr231-Pro Tau) in Primary Cortical Neurons.
Leila Aghababaee, Khadijeh Farrokhi, Mohammad Hossein Karimi-Jafari, Koorosh Shahpasand, Gholam Hossein Riazi
Published: 202510.1007/s12035-025-05454-8
Abstract
Tau is a microtubule-associated protein. Hyperphosphorylation of tau at neurotoxic sites, particularly at Thr231 within the Thr231-Pro motif, is a pathological hallmark of Alzheimer's disease (AD) and other tauopathies. Phosphorylated tau at Thr231 e…
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