Phosphodiesterase-4 Inhibition: An Experimental Approach to Overcome Drug Resistance in a Rotenone-Corneal 6 Hz Kindling Mouse Model of Drug-Resistant Epilepsy.

PDE4 upregulation reduces cAMP levels, leading to disrupted intracellular signaling and increased neuronal hyperexcitability. This contributes to neuroinflammation and neurodegeneration, potentially leading to cognitive decline in drug-resistant epil…

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