Medical oncology (Northwood, London, England)HumansMetforminApoptosisBreast NeoplasmsMechanistic Target of Rapamycin Complex 1
mTORC1 inhibition by metformin synergizes with dendrosomal nano-curcumin to induce apoptosis via modulation of pro- and anti-apoptotic proteins in breast cancer cells.
Zohreh Jahani, Majid Sadeghizadeh, Jamshid Davoodi
Published: 202510.1007/s12032-025-03227-w
Abstract
Breast cancer often carries a poor short-term prognosis because of its strong tendency for early distant metastasis and recurrence. Effective treatment requires strategies that disrupt the anabolic pathways cancer cells use to overcome therapeutic re…
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