Medical oncology (Northwood, London, England)MicroRNAsAnimalsHumansMiceLiver Neoplasms
Icaritin suppresses CAD-mediated liver cancer development by targeting miR-18b-5p in a xenograft mouse model.
Di Wu, Tian Mi, Xue Tang, Yiming Jia, Tao Guo, Guoqiang Zhou, Wenjuan Li
Published: 202510.1007/s12032-025-03211-4
Abstract
Cancer cells show abnormal nucleotide metabolism and prefer the de novo synthesis pathway. As the key enzymes, Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase (CAD) is overactivated in cancer and promotes pyrimidine…
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