Medical oncology (Northwood, London, England)HumansColorectal NeoplasmsAutophagyReceptorIGF Type 1
Combined inhibition of insulin growth factor 1 receptor and autophagy prevents colorectal cancer metastasis.
Eglal Mahgoub, Khuloud Bajbouj, Samrein Ahmed, Shirin Hafezi, Leen Eldohaji, Thenmozhi Venkatachalam, Mahmood Hachim, Tasneem Al Hamidi, Jasmin Shafarin, Wael M Abdel-Rahman, Nabil Sulaiman, Rifat Hamoudi, Jalal Taneera, Ritu Lakhtakia, Iman M Talaat
Published: 202510.1007/s12032-025-03179-1
Abstract
The role of Insulin-like growth factor 1 (IGF-1) in promoting cancer proliferation has been identified, yet its potential role in metastasis has not been fully elucidated. Autophagy plays a pivotal, yet controversial, role in regulating cancer cell b…
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