Medical oncology (Northwood, London, England)HumansCarcinomaHepatocellularLiver NeoplasmsProto-Oncogene Proteins c-myc
CCA-1.1 Destabilizes MYC proteins to induce irreversible anti-proliferative effects in hepatocellular carcinoma.
Rohmad Yudi Utomo, Novia Permata Hapsari, Nadzifa Nugraheni, Beni Lestari, Mila Hanifa, Ni Putu Linda Laksmiani, Ummi Maryam Zulfin, Daisuke Muto, Muthi Ikawati, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto, Riris Istighfari Jenie
Published: 202510.1007/s12032-025-03135-z
Abstract
N-Myc and c-Myc, as two major members of the MYC family proteins, independently contribute to hepatocellular carcinoma (HCC) by promoting proliferation, survival, and metabolic reprogramming. Overexpression of both proteins correlates with poor clini…
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