Journal of gastrointestinal cancerHumansImmune Checkpoint InhibitorsColorectal NeoplasmsNeoadjuvant TherapyMicrosatellite Instability
Neoadjuvant Immune Checkpoint Inhibition in MSI-H/dMMR Colorectal Cancer: A Systematic Review of Prospective Trials Evaluating Efficacy, Pathologic Response, and Surgical Outcomes.
Wajahat Mirza, Mehak Ejaz Khan, Hania Iqbal, Alishbah Khan, Muhammad Bilal Moeen-Ud-Din, Hadi Mohammad Khan, Sundas Dadan
Published: 202510.1007/s12029-025-01358-x
Abstract
BACKGROUND: Mismatch repair-deficient (dMMR) and microsatellite instability-high (MSI-H) colorectal cancers demonstrate exceptional responsiveness to immune checkpoint inhibitors; however, evidence for the efficacy of neoadjuvant immunotherapy remain…
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