Endocrine pathologyHumansImmunohistochemistryTumor Suppressor Protein p53Neuroendocrine TumorsBiomarkers
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing.
Ruiqian Chen, Matthieu Tihy, Ludovic Lacroix, Ophelie de Rycke, Caroline Lacombe, Pierre Alexandre Just, Aurelie Cazes, Magali Svrcek, Vincent Thomas de Montpreville, Martine Antoine, Jean Yves Scoazec, Louis de Mestier, Anne Couvelard, Jérôme Cros
Published: 202510.1007/s12022-025-09885-w
Abstract
Rb and p53 status helps distinguishing well from poorly differentiated high-grade neuroendocrine neoplasms (HG-NENs) and may predict response to platinum-based chemotherapy. Historically, gene and protein profile correlations for Rb and p53 were perf…
Preview only. Read the full abstract at the source