NeuroinformaticsMuscular AtrophyHumansNeuromuscular JunctionMaleTranscriptome
A Validated Transcriptomic NMJ Remodeling Score Reveals Synaptic Dysfunction Independent of Muscle Atrophy after Immobilization in a Microgravity Analog.
Rahul Kumar, Andrew Bouras, Karmen Gill, Kyle Sporn, Rohan Phadke, Harlene Kaur, Phani Paladugu, Joshua Ong, Ethan Waisberg, Andrew G Lee
Published: 202610.1007/s12021-026-09767-4
Abstract
Muscle weakness after immobilization often exceeds that explained by loss of muscle mass alone, suggesting a role for neuromuscular synaptic changes. To quantify these adaptations, we developed a composite transcriptomic Neuromuscular Junction (NMJ)…
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