Neuromolecular medicineAnimalsMiceCyclic AMP Response Element-Binding ProteinMaleTramadol
Aurintricarboxylic Acid Attenuates Tramadol Withdrawal Syndrome Via TWEAK/FN14 Inhibition and CREB Modulation in Mice Model.
Rajalaxmi, Shahid Nazir Wani, Amarjot Kaur Grewal, Varinder Singh, Amit Kumar, Heena Khan, Thakur Gurjeet Singh
Published: 202510.1007/s12017-025-08893-7
Abstract
Tramadol withdrawal presents a significant clinical challenge, characterized by neurobehavioral impairments linked to neuroinflammation, oxidative stress and neurotransmitter dysregulation. The TNF-like weak inducer of apoptosis (TWEAK)/fibroblast gr…
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