Biological trace element research
Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4.
Mengxue Zhao, Mengyao Xu, Wei Zhang, Mingye Tang, Shan Ji, Jie Shi
Published: 202510.1007/s12011-025-04896-4
Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, necessitating novel therapeutic strategies. This study demonstrates that high-dose sodium selenite (Na₂SeO₃) induces ferroptosis in CRC cells by directly targeting…
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