Applied biochemistry and biotechnology
DDX11/SKP2 Inhibits Cisplatin Sensitivity in Liver Cancer Cells by Regulating DNA Damage Repair and ER Stress.
Shujia Kong, Xin Pan, Jiaxun Li, Chen Zhao, Yanwen Li
Published: 202610.1007/s12010-025-05516-6
Abstract
Cisplatin is mainly used for treating terminal hepatocellular carcinoma (HCC), but the development of drug resistance limits its clinical efficacy in treating this disease. The helicase activity of DDX11 can prevent hypersensitivity to chemotherapy d…
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