In vitro cellular & developmental biology. AnimalPolycystic Ovary SyndromeFemaleAnimalsGranulosa CellsApoptosis
KLF5 drives granulosa cell apoptosis and inflammatory injury in polycystic ovary syndrome via transcriptional activation of TXNIP.
Ying Wang, Jiahui Liu, Yiqun Jiang, Yanzuo Liu, Hongying Kuang, Xiaoling Feng
Published: 202510.1007/s11626-025-01124-0
Abstract
Polycystic ovary syndrome (PCOS), a common endocrine disorder affecting over 10% of women, is characterized by hyperandrogenism and ovarian dysfunction. While linked to chronic inflammation and granulosa cell apoptosis, its molecular mechanisms remai…
Preview only. Read the full abstract at the source