Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune PharmacologyHumansGliomaMembrane GlycoproteinsReceptorsImmunologic
Lipid-Metabolically Active TREM2high Microglia‑Derived Macrophages Predict Poor Prognosis and Represent an Immunotherapeutic Target in Glioma.
Jinxin Li, Xiaotong Yu, Decao Yang, Shaomeng Chen, Jiaxing Xu, Xiaojuan Ma, Chen Huang, Baohui Xu, Lixiang Xue, Yan Wang
Published: 202510.1007/s11481-025-10250-1
Abstract
Gliomas are the most common primary brain tumors and characterized by poor prognosis and heavy infiltration of tumor-associated macrophages. Triggering receptor expressed on myeloid cells-2 (TREM2), known to modulate macrophage function, has shown co…
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