Forensic toxicology
Inactivation of calcium Ion signaling in neuronal SK-N-SH cells with development of resistance to a designer drug α-pyrrolidinooctanophenone.
Yuji Sakai, Yoshifumi Morikawa, Toshihiro Matsumura, Shunsuke Jimbo, Koichi Suenami, Gento Yamashita, Atsushi Nagai, Tomomi Michiue, Akira Ikari, Toshiyuki Matsunaga
Published: 202510.1007/s11419-025-00751-2
Abstract
PURPOSE: The cellular mechanisms underlying tolerance development to psychostimulant-induced neurotoxicity remain poorly understood. This study investigated these mechanisms using pyrrolidinophenone derivatives (PPs), potent amphetamine-type stimulan…
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