GeroScience
Cytokine-induced senescence in tumors is based on sustained activation of STAT1- and NFκB-dependent gene regulatory signatures.
Maximilian Rentschler, Mohamed Ali-Jarboui, Christoph M Griessinger, Michael Rosen, Grégory Doré, Oliver Bischof, Manfred Kneilling, Martin Röcken, Heidi Braumüller, Thomas Wieder
Published: 202610.1007/s11357-026-02100-6
Abstract
Senescence is a tripartite cellular phenotype characterized by permanent growth arrest, resistance to apoptosis, and high secretory activity. Besides its physiological role in embryonic development and pathophysiological contribution to age-related t…
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