GeroScience
Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging.
Nicholas J Kim, Ayati Mishra, Nahian F Chowdhury, Samuel D Anderson, Owen M Vega, Nikhil N Chaudhari, Kenneth H Buetow, Paul M Thompson, Andrei Irimia
Published: 202510.1007/s11357-025-02046-1
Abstract
Local brain age (LBA) is a regional metric of brain aging that offers a spatially resolved alternative to global brain age, but whose genetic basis is unexplored. This study reports the first genome-wide association study of cortical LBA, as estimate…
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